2021 Mercedes-Benz E 350 recalls and problems

The 2021 Mercedes-Benz E 350 has 12 safety recalls and 13 owner complaints filed with NHTSA. Recall repairs are free at any Mercedes-Benz dealer.

Recalls
12
Complaints
13
Crashes / fires
0 / 1
Injuries / deaths
0 / 0

Recalls may cover only some 2021 Mercedes-Benz E 350 vehicles. Check your VIN at NHTSA ↗ to see open recalls for your exact car.

2021 Mercedes-Benz E 350 recalls

Recall 23V-445: Fuel System, Gasoline

Reported Jun 26, 2023 · 143,551 vehicles affected · Mercedes-Benz USA, LLC

Problem: Mercedes-Benz USA, LLC (MBUSA) is recalling certain 2021-2023 C-Class, E-Class, S-Class, CLS, SL, GT, GLC, GLE, GLS, and G-Class vehicles. Please refer to MBUSA's recall report for specific vehicle details. The fuel pump may shutdown, which can result in a loss of drive power.

Risk: A loss of drive power can increase the risk of a crash.

Fix: Dealers will replace the fuel pump, free of charge. Owner notification letters were mailed on June 14, 2024. Owners may contact MBUSA customer service at 1-800-367-6372. MBUSA's number for this recall is 2023070012.

Recall 22V-365: Communication, Electrical System

Reported May 20, 2022 · 242,722 vehicles affected · Mercedes-Benz USA, LLC

Problem: Mercedes-Benz USA, LLC (MBUSA) is recalling certain 2017-2022 CLA-Class, GLA-Class, GLE-Class, GLS-Class, SLC-Class, A-Class, AMG GT-Class, C-Class, E-Class, S-Class, SL-Class, GLC-Class, CLS-Class, GLB-Class, and G-Class vehicles. Please refer to MBUSA's recall report for specific vehicle model details. An error in the communication module's SIM card software can cause a mobile network connection failure, disabling the emergency call (eCall) system.

Risk: A disabled eCall system would prevent a vehicle occupant from contacting the emergency services call center in an emergency, potentially delaying emergency responders and increasing the risk of injury.

Fix: The communication module software will be updated through an Over-the-Air (OTA) update or by a dealer, free of charge. Owner notification letters were mailed July 8, 2022. Owner notification letters will be mailed in phases, on July 8, 2022, May 17, 2024, July 29, 2024, and September 27, 2024. Owners may contact MBUSA customer service at 1-800-367-6372. MBUSA's numbers are for this recall is 2022060005 and 2023110006.

Recall 22V-232: Back Over Prevention

Reported Apr 8, 2022 · 126,443 vehicles affected · Mercedes-Benz USA, LLC

Problem: Mercedes-Benz USA, LLC (MBUSA) is recalling certain 2018-2021 CLA-Class, GLE/GLS-Class, A-Class, C-Class, E-Class, E-Class Coupe/Convertible, GLA/GLB-Class, GLC-Class, and CLS-Class vehicles. Please refer to MBUSA's recall report for specific vehicle model details. The rearview camera may not display the rearview image due to a software error. As such, these vehicles fail to comply with the requirements of Federal Motor Vehicle Safety Standard number 111, "Rear Visibility."

Risk: An inoperable rearview camera display reduces the driver's rear view, increasing the risk of a crash.

Fix: Dealers will update the rearview camera software, free of charge. Owner notification letters were mailed July 15, 2022. Owners may contact MBUSA customer service at 1-800-367-6372. MBUSA's number for this recall is 2022060007.

Recall 22V-189: Steering

Reported Mar 25, 2022 · 8,396 vehicles affected · Mercedes-Benz USA, LLC

Problem: Mercedes-Benz USA, LLC (MBUSA) is recalling certain 2021-2022 C-Class, E-Class, S-Class, SL, EClass Coupe/Convertible, CLS, AMG GT 4-doors Coupe, and EQS vehicles with a heated leather steering wheel. Due to a software error in the hand detection control unit, the hands-off detection might not detect when the driver's hands are away from the steering wheel when using the Active Distance Assist DISTRONIC system.

Risk: Deactivated hands-off detection will prevent DISTRONIC system features from functioning, including warnings to grab the steering wheel and calling first responders as part of the Active Emergency Stop Assist, which can increase the risk of a crash or injury.

Fix: Dealers will update the hand detection control unit software for the DISTRONIC system, free of charge. Owner notification letters were mailed May 6, 2022. Owners may contact MBUSA customer service at 1-800-367-6372. MBUSA's number for this recall is 2022040010.

Recall 21V-527: Air Bags

Reported Jul 12, 2021 · 542 vehicles affected · Mercedes-Benz USA, LLC

Problem: Mercedes-Benz USA, LLC (MBUSA) is recalling certain 2021 CLS450, AMG E53, AMG CLS53, E350, E450, AMG GT43, AMG GT53, 2020 S450, S560, G550, AMG GLC63, 2020-2021 GLC300, and AMG G63 vehicles. The side crash sensor connectors may come loose, which could delay the activation of air bags and seatbelts during a side impact crash.

Risk: Air bags and seatbelts that don't function as intended can increase the risk of injury during a crash.

Fix: Dealers will inspect and replace as necessary, the side impact crash sensors, free of charge. Owner notification letters were mailed on September 3, 2021. Owners may contact MBUSA customer service at 1-800-367-6372. MBUSA's number for this recall is 2021070032/33.

Recall 21V-483: Seat Belts

Reported Jun 25, 2021 · 4,917 vehicles affected · Mercedes-Benz USA, LLC

Problem: Mercedes-Benz, LLC (MBUSA) is recalling certain 2021 G550, AMG G63, E350, E450, AMG CLS53, AMG E53, AMG GT43, AMG GT53, AMG GT63, 2021-2022 CLS450, and AMG E63 vehicles. The rear seat belt automatic locking retractors may deactivate early, which can prevent the child restraint system from securing properly. As such, these vehicles fail to comply with the requirements of Federal Motor Vehicle Safety Standard number 208, "Occupant Crash Protection."

Risk: An unsecured child restraint system can increase the risk of injury during a crash.

Fix: Dealers will inspect, and replace as necessary, the rear seat belt assemblies, free of charge. Owners notified of the voluntary recall campaign by an interim letter on August 13, 2021. A final letter was mailed on September 24, 2021. Owners may contact MBUSA customer service at 1-800-367-6372.

Recall 21V-354: Back Over Prevention, Electrical System

Reported May 14, 2021 · 343,191 vehicles affected · Mercedes-Benz USA, LLC

Problem: Mercedes-Benz USA, LLC (MBUSA) is recalling certain 2019-2021 CLA-Class, GLE/GLS-Class, A-Class, E-Class, E-Class Coupe and Convertible, GLA/GLB-Class, GLC-Class, CLS-Class, and AMG GT-Class 4-door Coupe vehicles. Please refer to MBUSA's recall report for specific vehicle model details. The MBUX multimedia system software may cause the display to remain black, or reboot after startup. This could result in the rearview camera image not displaying properly. As such, these vehicles fail to comply with the requirements of Federal Motor Vehicle Safety Standard (FMVSS) number 111, "Rear Visibility."

Risk: A backup camera that displays a blank image reduces the driver's rear view, increasing the risk of a crash or injury.

Fix: The multimedia system software will be updated by a dealer, or through an over-the-air (OTA) update, free of charge. Owner notification letters were mailed beginning June 28, 2021. Owners may contact MBUSA customer service at 1-800-367-6373. MBUSA's number for this recall is 2021050012.

Recall 21V-230: Seat Belts, Air Bags, Seats

Reported Apr 1, 2021 · 8,634 vehicles affected · Mercedes-Benz USA, LLC

Problem: Mercedes-Benz USA, LLC (MBUSA) is recalling certain 2021 C-Class, E-Class, E-Class Coupe and Convertible, GLC, CLS, AMG GT 4-door Coupe and G-Class vehicles. Please refer to MBUSA's recall report for specific vehicle model details. A faulty electrical contact within the seat position switch may prevent the driver and passenger air bags and seat belt force limiters from properly activating during a crash.

Risk: Air bags and seat belts that do not perform properly in a crash can increase the risk of injury.

Fix: MBUSA will notify owners, and dealers will replace the seat position switches, free of charge. Owner letters were mailed May 21, 2021. Owners may contact MBUSA customer service at 1-800-367-6372. MBUSA's number for this recall is 2021040016.

Recall 21V-228: Back Over Prevention

Reported Apr 1, 2021 · 6 vehicles affected · Mercedes-Benz USA, LLC

Problem: Mercedes-Benz USA, LLC (MBUSA) is recalling certain 2021 E350, E450, E450 Wagon, and AMG E63 vehicles. The parking control unit may fail to display the rearview camera image and cause the parking sensors to misidentify or fail to detect objects.

Risk: An inoperative rearview camera display and/or parking sensors can reduce the driver's view and awareness of what is behind the vehicle, increasing the risk of a crash.

Fix: All affected vehicles are still within MBUSA's control. MBUSA will replace the parking control unit, free of charge. The recall began April 8, 2021. Owner may contact MBUSA customer service at 1-800-367-6372.

Recall 21V-216: Seats

Reported Mar 26, 2021 · 109 vehicles affected · Mercedes-Benz USA, LLC

Problem: Mercedes-Benz USA, LLC (MBUSA) is recalling certain 2021 E350, E450, E450 Wagon, E63S AMG, 2020 E63S AMG Wagon, and 2020-2021 E53 AMG vehicles. The passenger seat limiter may allow the seat to be positioned too close to the air bag.

Risk: A seat too close to the air bag increases the risk of injury in the event of a crash necessitating the deployment of the frontal passenger air bag.

Fix: MBUSA will notify owners, and dealers will recalibrate the passenger seat limiter, free of charge. The recall began April 29, 2021. Owners may contact MBUSA customer service at 1-800-367-6372. MBUSA's number for this recall is 2021040002.

Recall 21V-058: Communication, Electrical System

Reported Feb 5, 2021 · 1,292,258 vehicles affected · Mercedes-Benz USA, LLC

Problem: Mercedes-Benz USA, LLC (MBUSA) is recalling certain 2016 - 2021 CLA-Class, GLA-Class, GLE-Class, GLS-Class, SLC-Class, A-Class, GT-Class, C-Class, E-Class, S-Class, CLS-Class, SL-Class, B-Class, GLB-Class, GLC-Class, and G-Class vehicles. Please refer to the Part 573 report for specific vehicle model details. The software design of the communication module may fail to communicate the correct vehicle location for the emergency call system (eCall) in the event of a crash.

Risk: Failure of the eCall system may result in emergency responders being dispatched to the wrong location, increasing the risk of injury following a crash.

Fix: MBUSA will notify owners, and the communication module software will be updated by a dealer, or through an over-the-air (OTA) update, free of charge. The recall began March 12, 2021. Owners may contact MBUSA customer service at 1-877-762-8267. MBUSA's number for this recall is 2021020025.

Recall 20V-673: Seats

Reported Oct 30, 2020 · 1,337 vehicles affected · Mercedes-Benz USA, LLC.

Problem: Mercedes-Benz USA, LLC. (MBUSA) is recalling certain 2021 E350 and E450, 2019-2021 AMG E53 and 2020-2021 AMG E63 vehicles. The front passenger seat may be missing the mechanical seat adjustment range limit stop, allowing the seat to move outside of the acceptable range in relation to the air bag.

Risk: If the front passenger seat is adjusted beyond the acceptable range in relation to the air bag, there could be an increased risk of injury in the event of a crash with air bag deployment.

Fix: MBUSA will notify owners, and dealers will inspect for the mechanical seat adjustment range limitation for the front passenger seat and install it if necessary, free of charge. The recall began December 18, 2020. Owners may contact MBUSA customer service at 1-800-368-6372. MBUSA's number for this recall is 2020110013.

2021 Mercedes-Benz E 350 problems reported by owners

Problem areaReports
Back Over Prevention5
Engine4
Electrical System4
Power Train3
Fuel/Propulsion System2
Fuel System, Gasoline1
Service Brakes1

Most reported parts

  • Back Over Prevention › Warnings — 2
  • Back Over Prevention › Sensing System › Camera — 2
  • Back Over Prevention › Rearview System Braking — 1

Typical mileage at the time of the problem: 53,200 miles (median of owner reports).

Problems that are not covered by a recall are paid repairs; labor rates follow local mechanic pay — see what auto mechanics earn in each state.

Recent 2021 Mercedes-Benz E 350 complaints

Owner reports filed with NHTSA, as written (personal details removed). Complaints are not verified by NHTSA.

Electrical System · reported May 8, 2026
Vehicle: 2021 Mercedes-Benz E350 Sedan (W213) VIN: [XXX] While operating the vehicle, the diagnostic system displayed the fault code P240200 related to the Evaporative Emission Control System (EVAP). The warning message indicated a “positive short circuit” in the fuel vapor leak diagnosis pump control circuit. The malfunction appears to involve the EVAP diagnostic module and/or associated electrical wiring near the fuel system. The affected component may be available for inspection upon request. The issue raises safety concerns because the fault involves an electrical short circuit…
Power Train · reported Jan 4, 2026
With the car only have about 15,000 miles the transmission has failed . I have seen there have been recalls of other models with similar complaints of transmission failure .
Engine · reported Dec 27, 2025
Engine keeps having a misfire that Mercedes put a TSB out for and once the misfire happen I cause the vehicle to go in a limp mode which causes the vehicle to loose power happened to me in the freeway. The car had 54K miles and Mercedes refused to repair the issue as the engine part failure isn’t common.
Engine · reported Jul 14, 2025
My 2021 Mercedes-Benz E350 (VIN [XXX] ) developed a serious engine issue involving cylinder misfire and check engine light. The dealer diagnosed it as a leaking exhaust valve on cylinder 4, related to TSB LI01.30-P-072328, which documents valve seat wear in M260 engines. This is a known defect acknowledged by Mercedes in technical bulletins, and other customers in the U.S. have received warranty extensions or goodwill coverage. I was denied coverage even though this is a manufacturer defect that can lead to misfire, power loss, and potential stalling, posing a safety risk on the road.…
Power Train · reported Jul 10, 2025
The Mercedes E350, with 22,000 miles suffered a catastrophic transmission failure while driving on the highway. I managed to exit the highway but the car could not be moved and left me stranded.

Other Mercedes-Benz E 350 years

Compare all Mercedes-Benz E 350 years · All Mercedes-Benz models

Frequently asked questions

Does the 2021 Mercedes-Benz E 350 have any recalls?

Yes — NHTSA lists 12 recalls for the 2021 Mercedes-Benz E 350: 23V-445 (fuel system, gasoline), 22V-365 (communication, electrical system), 22V-232 (back over prevention), 22V-189 (steering), 21V-527 (air bags) and more. Not every vehicle is affected, so check your VIN at nhtsa.gov/recalls.

What is the most common problem with the 2021 Mercedes-Benz E 350?

Owners report back over prevention problems most often (5 reports), followed by engine (4). The typical mileage when problems were reported is about 53,200 miles.

Are Mercedes-Benz recall repairs free?

Yes. Safety recall repairs are free at authorized Mercedes-Benz dealers, whether you are the first owner or bought the car used.